Intratumoral immunotherapy of murine pheochromocytoma shows no age-dependent differences in its efficacy

Uher, Ondrej and Hadrava Vanova, Katerina and Lencova, Radka and Frejlachova, Andrea and Wang, Herui and Zhuang, Zhengping and Zenka, Jan and Pacak, Karel (2023) Intratumoral immunotherapy of murine pheochromocytoma shows no age-dependent differences in its efficacy. Frontiers in Endocrinology, 14. ISSN 1664-2392

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Abstract

Cancer immunotherapy has shown remarkable clinical progress in recent years. Although age is one of the biggest leading risk factors for cancer development and older adults represent a majority of cancer patients, only a few new cancer immunotherapeutic interventions have been preclinically tested in aged animals. Thus, the lack of preclinical studies focused on age-dependent effect during cancer immunotherapy could lead to different therapeutic outcomes in young and aged animals and future modifications of human clinical trials. Here, we compare the efficacy of previously developed and tested intratumoral immunotherapy, based on the combination of polysaccharide mannan, toll-like receptor ligands, and anti-CD40 antibody (MBTA immunotherapy), in young (6 weeks) and aged (71 weeks) mice bearing experimental pheochromocytoma (PHEO). The presented results point out that despite faster growth of PHEO in aged mice MBTA intratumoral immunotherapy is effective approach without age dependence and could be one of the possible therapeutic interventions to enhance immune response to pheochromocytoma and perhaps other tumor types in aged and young hosts.

Item Type: Article
Subjects: Open Digi Academic > Mathematical Science
Depositing User: Unnamed user with email support@opendigiacademic.com
Date Deposited: 07 Jul 2023 04:06
Last Modified: 05 Sep 2024 11:21
URI: http://publications.journalstm.com/id/eprint/1289

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