Reproductive Toxicity & Biomarker Response of Male Albino Rats (Rattus norvegicus) to a Daily Dose of Local Gin (Ogogoro)

This study evaluates the effect of local gin (ogogoro) on Hepato-renal parameters such as aspartate amino transferase, alanine amino transferase, sodium, potassium, chlorine and bicarbonate, haematological parameters such as total protein, packed cell volume, red blood cell, white blood cell haemoglobin, platelet and lymphocytes and sperm count parameter.

The results show that: The mean serum electrolytes were for week 1 (Na 165.0, K 5.27, Cl 99.67 and HCO3 19.67), week 2 (Na 138, K 5.77, Cl 89.67 and HCO3 20), week 3 (Na 126.67, K 3.67, Cl 87.67 and HCO3 19) and week 4 (Na 117.67, K 2.70, Cl 73.67 and HCO3 22) and showed a significant difference in Na, Cl and HCO3 only when compared with the average control at (P<0.05), AST had a mean of 30.0 in week 1 which increased to 45.0 in week 4 while ALT had a mean of 15.0 in week 1 and increased to 30.67 in week 4. The mean serum protein reduced from 51.15 in week 1 to 42.53 in week 4 with significant difference (P<0.05). Mean PCV reduced from 36.0 in week 1 to 24.40 in week 4, Hb from 12.07 in week 1 to 8.80 in week 4 with a significant difference (P<0.05) when comparing the test with the average control, WBC from 6.17 in week 1 to 5.40 in week 4, Platelet increased from a mean of 255 on week 1 to 683 on week 4 with significant difference (P<0.05), RBC had a mean of 5.27 in week 1 and 5.25 on week 4 with no significant difference (P>0.05). Lymphocyte reduced from a mean of 69.0 week 1 to 45.50 in week 4 but when the test was compared with the average control it had a significant difference (P<0.05). While the mean sperm count was 275 in week 1 and 325 in week 4. These investigations demonstrated that local gin changes blood parameters which could lead to anaemia in mammals when constantly taken and also cause a detrimental effect on sperm count which could cause infertility in males as well as kidney and liver disease.